A non-coding cationic lipid DNA complex produces lasting anti-leukemic effects
نویسندگان
چکیده
منابع مشابه
Supramolecular polymorphism of DNA in non-cationic Lα lipid phases.
The structure of a complex between hydrated DNA and a non-cationic lipid is studied, including its phase diagram. The complex is spontaneously formed by adding DNA fragments (ca. 150 base pairs in length) to non-cationic lipids and water. The self-assembly process often leads to highly ordered structures. The structures were studied by combining X-ray scattering, fluorescence and polarized micr...
متن کاملModeling of cationic lipid-DNA complexes.
Cationic lipid-DNA complexes, often referred to as lipoplexes, are formed spontaneously in aqueous solutions upon mixing DNA and liposomes composed of cationic and nonionic lipids. Understanding the mechanisms underlying lipoplex formation, structure and phase behavior is crucial for their further development and design as non-viral transfection vectors in gene therapy. From a physical point of...
متن کاملComputational modeling of DNA-cationic lipid complexation.
Developments in gene therapy have led to a need for new and more efficient transfection vectors. So far, the use of viruses has received major attention. During the recent years, however, cationic liposomes have emerged as a potential rival for viruses and have several advantages, e.g. nonimmunogenity, low toxicity and a capability to carry larger amounts of DNA. Yet, the properties of cationic...
متن کاملDNA interaction with freestanding cationic lipid bilayers
We study the interaction of ds-DNA molecules with freestanding and supported cationic lipid bilayers. DNA fragments of different lengths (5, 10, 20, and 48 kbp) were adsorbed on lipid membranes consiting mainly of zwitterionic DOPC with added fractions of cationic DOTAP (1...10 %). Freestanding bilayers were modeled using giant unilamellar vesicles of sizes >100 μm. Supported lipid bilayers wer...
متن کاملCationic lipid/DNA complex-adjuvanted influenza A virus vaccination induces robust cross-protective immunity.
Influenza A virus is a negative-strand segmented RNA virus in which antigenically distinct viral subtypes are defined by the hemagglutinin (HA) and neuraminidase (NA) major viral surface proteins. An ideal inactivated vaccine for influenza A virus would induce not only highly robust strain-specific humoral and T-cell immune responses but also cross-protective immunity in which an immune respons...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2010
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.10.6.12653